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Watching prairie dogs flip up in the air, turn inside out and rain pieces has always brought a smile to my face, especially after nearly breaking my ankle so many times in the pot holes they leave everywhere. We have a nearly endless supply of them here in Wyoming and ranges of well over 250 yards are very common. The 204 Ruger has a muzzle velocity of around 4,000 feet per second [give or take a hundred] - The little bullets are about the same weight as an average .22 round but they are smaller and so much faster than the 1100 feet per second velocity of a .22. If the wind is blowing, this is not your winning combo but it has very little kick and it does not bark too loud.

I originally used H335 and had great luck with accuracy but H335 became very difficult to get so I worked up a load for W748 - I did also get an extra 100 ft/sec over the H335 load for the 40gr bullet.

Here are (7) 5 shot groups

20190928 204ruger   40G horn vmax W748 WSM primer   used brass    
  1 2 3 4 5 powder chg average deviation spread min max  
1 3631 3629 3658 3710 3794 27.1 3684.4 62.10507 165 3629 3794 1
2 3874 3853       27.3 3863.5 10.5 21 3853 3874 2
3 3697 3753 3663 3661 3686 27.5 3692 33.41856 92 3661 3753 3
4 3695 3730 3765 3726 3717 27.7 3726.6 22.7033 70 3695 3765 4
5 3746 3684 3828 3738 3715 27.9 3742.2 48.00167 144 3684 3828 5
6   3698 3718 3801 3771 28.1 3747 41.03048 103 3698 3801 6
7 3816 3837 3810 3774 3862 28.3 3819.8 29.27388 88 3774 3862 7

Like I was mentioning, the best accuracy is not always the best consistency as shown by the table above and the targets below

I ultimately did a compromise between group 4 and group 5 - this is where both accuracy and consistency was the best. Any little breeze influences this round so there is a bit of guess on the accuracy part but the standard deviation is most acceptable with a charge weight of 27.8gr